Fig. 4.

Deletion of RIP3 prolongs the lifespan of the atherosclerotic mice. (A and B) Comparison of survival of ApoE single-knockout and RIP3/ApoE double-knockout male (A) and female (B) mice. Survival curves start with 8-wk-old mice fed high-cholesterol diets (1.25%). ApoE single-knockout mice exhibited significantly decreased survival relative to RIP3/ApoE double-knockout mice. (C and D) Survival curves of ApoE single-knockout and RIP3/ApoE double-knockout male (C) and female (D) mice fed normal diets and recorded age at death. Data were analyzed with Kaplan–Meier tests. Asterisks denote the level of statistical significance between ApoE single-knockout and RIP3/ApoE double-knockout male and female mice: ***P < 0.001.