Table 3.
Cognitive and functional performance summaries by ApoE4 geneotype.
| N | E4− | E4+ | Combined | P-value | |
|---|---|---|---|---|---|
| Direct testing | |||||
| CAMCOG-DS | 12 | 58.2 (23.4) | 56.5 (20.3) | 57.3 (20.9) | 0.81 |
| Goodenough-DAP | 12 | 14.83 (9.47) | 17.33 (2.73) | 16.08 (6.78) | 0.81 |
| RBANS Composite | 12 | 259.3 (30.1) | 249.7 (47.1) | 254.5 (38.0) | 0.47 |
| RBANS Digit span | 12 | 4.67 (2.07) | 3.33 (2.66) | 4.00 (2.37) | 0.27 |
| RBANS List recall | 12 | 14.67 (3.98) | 11.83 (3.54) | 13.25 (3.89) | 0.18 |
| RBANS Memory | 12 | 50.00 (6.66) | 49.50 (13.17) | 49.75 (9.96) | 0.68 |
| RBANS Language | 12 | 70.8 (19.9) | 60.7 (16.3) | 65.8 (18.2) | 0.22 |
| Delayed Memory | 12 | 43.00 (3.79) | 43.17 (7.76) | 43.08 (5.82) | 0.44 |
| CANTAB-Total | 12 | 87.5 (33.2) | 109.0 (33.6) | 98.2 (33.8) | 0.29 |
| Dalton Dyspraxia | 12 | 205.7 (41.3) | 177.7 (49.9) | 191.7 (46.1) | 0.31 |
| Informant-based | |||||
| ADAMS | 12 | 17.8 (17.4) | 17.8 (23.3) | 17.8 (19.6) | 0.81 |
| Vineland-2 | 12 | 124.217 (32.9) | 96.767 (24.5) | 110.4 (31.2) | 0.24 |
| OMQ-PF | 12 | 91.5 (27.1) | 89.8 (27.3) | 90.7 (26.0) | 0.69 |
Higher score on all cognitive tests indicates better performance. The only exception is higher score on ADAMS, which indicates increased symptoms of anxiety, depression, agitation. ADAMS, Anxiety Depression and Mood Scale; CAMCOG-DS, Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities-Cognitive scale; Goodenough DAP, Goodenough-Harris Draw a Person test; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; (CANTAB), Cambridge Neuropsychological Test Automated Battery; OMQ-PF, Observer Memory Questionnaire (Parent Form).