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. 2015 Sep 14;6:471. doi: 10.3389/fimmu.2015.00471

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Copyright © 2015 Leliefeld, Koenderman and Pillay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Localization of interaction between neutrophils and lymphocytes at sites of inflammation and in lymphoid tissue. Invasion of pathogens or inflammation due to necrosis and cancer leads to extravasation of neutrophils. (1) Interaction of neutrophils with T-cells in the peripheral tissue. (2) MAC-1 and CXCR4-dependent migration of neutrophils to LNs via afferent lymphatics during inflammation (22). (3) IL17 and CCL21-mediated migration of neutrophils via HEVs to the LN that requires MAC-1, LFA-1, and l-selectin (19, 20). (4) Inhibition of humoral responses by neutrophils in the IFZ and medullar region (23). HEV, high endothelial venule; FZ, follicular zone; IFZ, interfollicular zone.