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Inhibitory activities of EhCS inhibitors from the Kitasato Natural Products Library.
| Compound | IC50 (μM) |
|
|---|---|---|
| CS1 | CS3 | |
| Kerriamycin B | 0.63 ± 0.07 | 0.31 ± 0.01 |
| Kerriamycin C | 1.2 ± 0.04 | 0.56 ± 0.04 |
| Aggreticin | 0.98 ± 0.05 | 0.64 ± 0.10 |
| Deacetylkinamycin C | 21 ± 2.4 | 22 ± 3.7 |
| Deoxyfrenolicin | 57 ± 2.0 | 53 ± 1.1 |
| Nanaomycin A | 53 ± 3.9 | 65 ± 4.4 |
| Naphthacemycin A9 | 75 ± 1.8 | >490 |
| Tetracycline | 170 ± 16 | 190 ± 9.5 |
| Patulin | 490 ± 81 | 470 ± 37 |
