Table 2.
In vitro anti-amebic activity and cytotoxicity against MRC-5 cells of EhCS inhibitors.
| Compound | Cytotoxicity |
||
|---|---|---|---|
| Against Entamoeba histolytica IC50 (μM) |
Against MRC-5 cells IC50 (μM) | ||
| Cys (+) | Cys (–) | ||
| Kerriamycin B | 26 ± 1.5 | 23 ± 0.3 | 21 ± 0.4 |
| Kerriamycin C | 6.9 ± 0.4 | 3.0 ± 0.6 | 23 ± 1.9 |
| Aggreticin | 54 ± 4.8 | 18 ± 0.7 | 23 ± 0.6 |
| Deacetylkinamycin C | 140 ± 13 | 18 ± 10 | 2.3 ± 0.1 |
| Deoxyfrenolicin | 1.3 ± 0.04 | 0.5 ± 0.1 | 4.7 ± 0.2 |
| Nanaomycin A | 12 ± 0.4 | 0.8 ± 0.04 | 0.7 ± 0.04 |
| Naphthacemycin A9 | >390 | >390 | 16 ± 0.6 |
| Tetracycline | >230 | >230 | 430 ± 4.3 |
| Patulin | >650 | 110 ± 12 | 110 ± 4.6 |
| Xanthofulvin | >170 | >170 | NT |
| Exophillic acid | >140 | >140 | >100 |
NT, Not tested. Cys (+), normal BI-S-33 medium (8 mM L-cysteine); Cys (–), cysteine deprived BI-S-33 medium.