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(1) APC2 assembles with Axin via its Arm rpts and SAMPs. (2) APC2-bound βcat is phosphorylated by CK1 and GSK3. (3) GSK3 and CK1 phosphorylate R2/B region in APC2. (4) This induces a conformational change that releases APC2's Arm rpts from Axin. (5) APC2-bound βcat is released to the E3-ligase—alternately an APC–βcat complex is released. (6) Dephosphorylation resets the cycle.
