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. 2015 Aug 8;5(11):1187–1202. doi: 10.7150/thno.11835

Figure 5.

Figure 5

Acute or chronic renal insufficiencies do not promote endothelial activation in distal organs. (A) Representative immunohistological VCAM-1 images of the brain hippocampus and cortex 48 hours after glycerol injection. Collagen type IV (Red) and DAPI (Blue) were used to assess brain tissue morphology. (B) Corresponding quantifications, demonstrating the lack of VCAM-1 upregulation in the brain (neither in the hippocampus nor cortex) after rhabdomyolysis (glycerol treatment), as compared to controls (saline), (n=5/group). ns=non significative differences were observed. (C) Top: Representative T2*-weighted images of the brain from control (saline) and glycerol-treated mice after MPIO-αVCAM-1 administration, 48 hours after rhabdomyolysis induction. Bottom: Corresponding quantification (n=5/group). (D) Experimental design. (E) Left: Representative T2*-weighted images of the kidneys and brain of control (Sham) and subtotal nephrectomized mice (SNX), after MPIO-αVCAM-1 administration. Right: Corresponding quantifications (n=5/group). (F) Kidney function assessed by BUN levels (n=6/group). (G) Schematic representation of the results. *p<0.05 vs control (Sham). ns= non significant differences were observed.