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. 2015 Aug 9;5(11):1214–1224. doi: 10.7150/thno.12403

Figure 2.

Figure 2

Serum proteins showing differential abundance between ETA/MTX responder and non-responder RA patients prior to treatment initiation. (A) Table shows the 11 proteins over-expressed in R serum samples and the unique protein (transferrin, TRFE) over-expressed in NR serum samples identified by mass spectrometry. Np is the number of peptides above significance threshold allowing protein quantitation and the associated protein sequence coverages. Confident score is the value extracted from Progenesis LCMS calculating after importing Mascot search results and restricted to the peptides used for quantitation. Fold change refers to the ratio of protein abundance in responders samples divided by the one of non-responders samples. The associated p-value, given in the last column is significant if p-value is < 0.05 (Mann-Whitney test). Illustration of relative quantification for proteins PROS (B) and CO7 (C) at baseline between R and NR samples. The results are presented as mean ± SEM. Ceruloplasmin : CERU; complement C1r subcomponent : C1R; complement component C7: CO7; inter-alpha-trypsin inhibitor heavy chain ITIH, C1-inhibitor : IC1, plasminogen : PLMN, vitamin K-dependent protein S: PROS, protein S100A9 : S100A9, transferrin : TRFE; zinc-alpha2-glycoprotein : ZA2G.