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. 2015 Sep 14;5:13958. doi: 10.1038/srep13958

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Simulated short-term dynamics of response to A. fumigatus challenge in (a) immunocompetent and (b) neutropenic hosts. Blue, cyan, red and pink depict fungal burden (F, [10⁶ CEs]), cytokines (C, [ng/ml]), recruited neutrophils (N, [10⁶ cells]) and recruited iDCs (D [10⁶ cells]), respectively. Solid lines represent model time-course and crosses represent the experimental data points used for parameter estimation²⁰,²⁴.