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. 2015 Sep 14;5:13989. doi: 10.1038/srep13989

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Copyright © 2015, Macmillan Publishers Limited

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(A) Schematic of cellular energy-converting pathways and inhibitors used to profile MEFs’ bioenergetics. FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; OLA, oligomycin A. (B,C) Oxygen consumption rates (OCR) in wild type (OMA1^+/+) and oma1^−/− MEFs under basal, OLA- and FCCP-stimulated conditions. Cells were cultured in the media containing 10 mM glucose (B) or 10 mM galactose (C). Data are shown as mean ± S.E.M. (n = 3 biological replicates); *p < 0.05, **p < 0.01, ***p < 0.001 (unpaired t-test). (D,E) Respiratory control ratios (a ratio between FCCP-stimulated OCR and basal OCR) in OMA1^+/+ and oma^−/− cells cultured in 10 mM glucose (D) or 10 mM galactose (E). Error bars indicate S.D.; p values are relative to control.

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