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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Biomaterials. 2015 Feb 23;52:79–87. doi: 10.1016/j.biomaterials.2015.02.016

Figure 1. Bioreactor design and ILC setup.

Figure 1

a. Custom cannulas for interfacing lung physiology with the bioreactor. Pulmonary vein (PV). Pulmonary artery (PA). Trachea (T). Auxiliary (Aux.).

b. Cannulated porcine lungs on ice prior to being placed inside the bioreactor for isolated lung culture.

c. Cannulated porcine lungs inside the bioreactor organ chamber during isolated lung culture.

d. Schematic layout of the clinical scale lung bioreactor.

e. Photograph of the bioreactor setup in an incubator.

f. Example perfusion pressure (top) and flow (bottom) traces from isolated lung culture. PPA bar, mean pulmonary artery pressure; f, frequency; SV, stroke volume; Qmax, maximum arterial flow.

g. Example ventilation volume (top) and pressure (bottom) traces from isolated lung culture. Discontinuity in top plot represents volume exiting PEEP valve. VT, tidal volume; RR, respiratory rate; PT, trachea pressure; POC, organ chamber pressure; I, inspiratory time; E, expiratory time.

h. Diagram of forces acting on the lung in vivo.