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. 2015 Sep 14;16(1):189. doi: 10.1186/s13059-015-0765-3

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© Couso. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The number of small open reading frames (smORFs) in eukaryotic genomes (shown in log scale) greatly exceeds that of annotated protein-coding genes, and reaches 265,000 in yeast [4], 556,000 in the fruit fly Drosophila [2], and 40,700,000 in mouse [3]. Note that the current number of corroborated functional smORFs is but a small fraction of these (see text and [1] for details). The number of annotated protein-coding genes was obtained from the Saccharomyces Genome Database (yeast; http://www.yeastgenome.org/), FlyBase (fruit fly; http://flybase.org/), and Ensembl (mouse; http://www.ensembl.org/index.html) (accessed 12 August 2015)