Table 2.
Basic information on the five SNPs and Pearson Chi-square test at 6q25.1 between CCDC170-ESR1
| SNPs | Chr | Position | Nearby Gene | Distance | A/B | MAF-control | MAF-case | HWE-p | OR | 95% CI | p-χ2 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs3757318 | 6 | 151955806 | CCDC170 | 98886||28215 | A/G | 0.286 | 0.247 | 0.656 | 1.30 | 1.08-1.56 | 0.005* |
| rs3734805 | 6 | 151981043 | CCDC170 | 124123||2978 | C/A | 0.315 | 0.300 | 0.922 | 1.28 | 1.08-1.53 | 0.006* |
| rs2046210 | 6 | 151990059 | CCDC170-ESR1 | -6038||-180320 | T/C | 0.351 | 0.363 | 0.858 | 1.20 | 1.02-1.42 | 0.033* |
| rs9383938 | 6 | 152029050 | CCDC170-ESR1 | -45029||-141329 | T/G | 0.405 | 0.375 | 0.860 | 1.09 | 0.92-1.29 | 0.322 |
| rs9383951 | 6 | 152337306 | ESR1 | 166927||128793 | C/G | 0.089 | 0.105 | 0.663 | 0.89 | 0.67-1.17 | 0.392 |
A/B: Minor/major alleles based on the control sample frequencies. HWE: Hardy-Weinberg equilibrium test among controls.
*
p < 0.05 indicates statistical significance.
A: Minor alleles. B: Major alleles. SNPs: Single nucleotide polymorphisms. Chr: Chromosome. MAF: Minor allele frequency. OR: Odds ratio. CI: Confidence interval.