Table 3.

Allele frequencies in cases and controls and odds ratio estimates for Laryngeal, Esophageal, Gastric and Colorectal Cancer

SNP_ID	Gene	Band	Position	Allele A/Ba	MAF			HWE P-value	Laryngeal Cancer			Esophageal Cancer
					Laryngeal Cancer Case	Esophageal Cancer Case	Control		ORs	95% CI	P value	ORs	95% CI	P value
rs3805322	ADH4	4q23	100056998	G/A	0.483	0.462	0.432	0.48	1.229	0.947-1.595	0.12	1.129	0.909-1.402	0.273
rs1042026	ADH1B	4q23	100228466	A/G	0.387	0.279	0.287	0.04#	1.567	1.184-2.074	0.002	0.959	0.755-1.217	0.729
rs1229984	ADH1B	4q23	100239319	G/A	0.365	0.355	0.385	0.64	0.917	0.700-1.201	0.529	0.878	0.703-1.097	0.252
rs1789924	ADH1C	4q23	100274286	T/C	0.031	0.077	0.092	0.27	0.311	0.161-0.602	< 0.001*	0.819	0.556-1.207	0.313
rs971074	ADH7	4q23	100341861	A/G	0.128	0.129	0.173	0.37	0.702	0.484-1.020	0.062	0.711	0.526-0.962	0.027*
SNP_ID	Gene	Band	Position	Allele A/Ba	MAF			HWE P-Value	Gastric Cancer			Colorectal Cancer
					Gastric Cancer Case	Colorectal Cancer Case	Control		ORs	95% CI	P value	ORs	95% CI	P value
rs3805322	ADH4	4q23	100056998	G/A	0.440	0.440	0.460	0.03#	0.923	0.790-1.079	0.316	0.923	0.780-1.093	0.354
rs1042026	ADH1B	4q23	100228466	A/G	0.279	0.290	0.272	0.45	1.036	0.870-1.232	0.693	1.096	0.910-1.321	0.333
rs1229984	ADH1B	4q23	100239319	G/A	0.368	0.378	0.362	0.17	1.027	0.874-1.206	0.745	1.069	0.899-1.271	0.452
rs1789924	ADH1C	4q23	100274286	T/C	0.106	0.110	0.107	0.84	0.988	0.769-1.270	0.928	1.029	0.787-1.347	0.83
rs971074	ADH7	4q23	100341861	A/G	0.148	0.147	0.154	0.47	0.952	0.767-1.183	0.66	0.947	0.748-1.198	0.649

^aMinor allele;

^#site with HWE P ≤ 0.05 is excluded;

^* P value ≤ 0.05 indicates statistical significance;

HWE, Hardy-Weinberg Equilibrium; ORs, odds ratios; CI: confidence interval.