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Population pharmacokinetic parameters for abiraterone patients
| Abiraterone | ||
|---|---|---|
| Parameter | Fasting status Mean (SD) | Fed status Mean (SD) |
| Apparent Clearance / bioavailability [CL/F] (L/h) | 2650 (4617) | 231 (97.7) |
| Apparent Volume of distribution / bioavailability [Vd/F] (L) | 25494 (18670) | 4069 (1462) |
| Absorption rate (1/h) | 1.65 (0.33) | 1.65 (0.33) |
F = oral bioavailability
Absorption rate is fixed to be 1.65 1/h with standard deviation of 0.33.1/h.
