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Population pharmacokinetic parameters for nilotinib patients
| Nilotinib | ||
|---|---|---|
| Parameter | Fasting status Mean (SD) | Fed status Mean (SD) |
| Apparent Clearance / bioavailability [CL/F](L/h) | 33 (18) | 27(15) |
| Apparent Volume of distribution / bioavailability [Vd/F] (L) | 720 (267) | 604(181) |
| Absorption rate (1/h) | 0.74 (0.15) | 0.74 (0.15) |
F = oral bioavailability
Absorption rate is fixed to be 0.74 1/h with standard deviation of 0.15 1/h.
