Table 3.

Bias and precision of abiraterone oral clearance at the population level and individual level, between-individual variability, and between-occasion variability

Between-occasion variability	Number of patients in trial	Oral Clearance – Population level		Oral Clearance – Individual level		Between-individual variability		Between-occasion variability		Food effect
		Bias	Precision	Bias	Precision	Bias	Precision	Bias	Precision	Bias	Precision
10%	20	−32.3%	37.1%	1.5%	14.5%	−44%	45.6%	−30%	40.7%	2.65%	9.95%
	50	−36.6%	37.8%	1.3%	14.6%	−43.6%	44.5%	−25.8%	30.8%	4.42%	7.42%
	70	−36.8%	37.8%	1.4%	14.9%	−43.3%	43.5%	−15.3%	23.3%	3.84%	6.81%
25%	20	−31.7%	36.6%	3.3%	19.6%	−45.1%	45.9%	−5.85%	18.8%	2.36%	11.8%
	50	−36.3%	37.6%	1.2%	18.9%	−42.4%	42.8%	−5.51%	14.6%	4.16%	8%
	70	−36.9%	37.9%	3.2%	19.9%	−43 %	43%	−3.08%	14.8%	3.61%	7.22%
40%	20	−31%	36.2%	1.4%	19.7%	−44.9%	46.1%	−1.34%	17.4%	2.01%	14.4%
	50	−35.7%	37.1%	1.6%	19.9%	−42.1%	42.8%	−1.44%	13.4%	2.52%	11.9%
	70	−37%	38.1%	4.4%	19.6%	−42.6%	43%	−1.11%	11.6%	2.64%	8.6%