Table 4.

Bias and precision of nilotinib oral clearance at the population level and individual level, between-individual variability, and between-occasion variability

Between-occasion variability	Number of patients in trial	Oral Clearance – Population level		Oral Clearance – Individual level		Between-individual variability		Between-occasion variability		Food effect
		Bias	Precision	Bias	Precision	Bias	Precision	Bias	Precision	Bias	Precision
10%	20	−11.8%	16.0%	−0.6%	4.6%	−9.0%	18.1%	−3.9%	11.0%	−0.12%	12.3%
	50	−12.0%	16.3%	−0.5%	4.3%	−9.9%	13.4%	−2.1%	6.9%	−0.05%	12.3%
	70	−12.8%	14.2%	−0.5%	4.2%	−8.0%	11.3%	−2.3%	5.7%	−0.04%	6.3%
25%	20	−12.0%	16.2%	−1.5%	6.6%	−8.8%	18.5%	−1.9%	8.9%	−0.4%	30%
	50	−12.4%	16.7%	−1.0%	6%	−9.1%	13.1%	−1.2%	5.2%	0.9%	20.9%
	70	−13.3%	14.7%	−0.8%	5.7%	−7.9%	11.7%	−0.9%	4.9%	−1.39%	15.5%
40%	20	−12%	16.4%	−1.9%	8.6%	−8.5%	19.4%	−1.8%	8.7%	11.8%	38.8%
	50	−12.7%	17.0%	−1.0%	7.2%	−9.2%	13.9%	−0.4%	7.7%	2.32%	30%
	70	−13.3%	14.7%	−0.9%	7.1%	−7.9%	12.3%	−0.7%	4.9%	−2.16%	24.3%