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. 2015 Apr 20;19(9):2084–2097. doi: 10.1111/jcmm.12563

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Genes included in the TNF-α-induced apoptosis pathway. The levels of miR-181c in the whole cells significantly increased after transfected with mimic (P < 0.05) and significantly decreased with inhibitor (P < 0.05) (A). While the levels of pre-miR-181c showed the trend of change, they did not reach statistical significance (P > 0.05) (B). The genes Bcl-2, Cyto-c and caspase-3, which are associated with the severity of heart failure and apoptosis of myocardial cells, were examined using RT-PCR. Their mRNA expression showed no significant difference (P > 0.05) (C–F).