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. 2015 Apr 20;19(9):2084–2097. doi: 10.1111/jcmm.12563

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The mouse myocardial cells, transfected with miR-181c mimic/inhibitor, were intervened with TNF-α and underwent the TEM scan. There were no significant changes in the gross morphology of myocardial cells and the number of mitochondria between groups (A–F, magnification: 4000 × to 30000 × ). The mitochondria showed abnormal appearance such as disorganization, rupture of the double membrane and reduction or vanish of the crista after TNF-α intervention. The severity of mitochondrial damage were for mimic group>control group>inhibitor group (G, magnification: 50000 × ).