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. 2015 Jun 23;19(9):2273–2285. doi: 10.1111/jcmm.12619

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Increased APLNR level in mice and human kidney. (A) Immunostating of APLNR in mice kidney. (B) The APLNR levels in the kidney of type 2 diabetic mice (kk-Ay mice) was significantly increased by 2.7-fold compared with that of control mice (C57BL). The data are expressed as the means ± SD (n = 6, *p < 0.01 versus control group). (C) APLNR level in the kidney of type 2 diabetic patients was significantly increased by 1.9-fold compared with that of control patients. The data are expressed as the means ± SD (n = 6, *p < 0.01 versus control group).