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Apelin impairs proteasome peptidase activities in kk-Ay mice. (A) Polyubiquitinated proteins were increased in kk-Ay mice and aggravated by apelin while reversed by F13A (n = 3). (B) 26S proteasome activities are indicated as percentages of those in C57BL mice. All proteasome activities decreased in kk-Ay mice compared with C57BL mice and aggravated by apelin while reversed by F13A (n = 8; mean ± SD, *p < 0.05 versus control, #p < 0.05 versus kk-Ay mice).
