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. 2015 Jul 6;19(9):2286–2295. doi: 10.1111/jcmm.12623

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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In vivo evaluation of radio-sensitivity in untransfected or stably transfected A549 xenografts. (A and B) Western blot and real-time PCR analysis of NRP1 expression in tumour tissues from each group of mice. The levels of NRP1 protein were significantly downregulated in tumour tissues from sh-A549 cells. (C) The growth of tumours was assessed by measuring tumour volume. The growth of tumours formed from shNRP1-A549 cells treated with irradiation developed slower than tumours from control cells treated with irradiation. (D and E) At d22, the mice were killed and the tumour volume was calculated. The volume of tumours from shNRP1-A549 cells treated with irradiation was significantly reduced by approximately 13% compared with that of tumours formed from A549 cells.