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. 2015 Jul 6;19(9):2286–2295. doi: 10.1111/jcmm.12623

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A–C) The effect of X-ray irradiation on the migration and invasion of A549 cells in vitro. A549 cells treated with 10 Gy X-rays, shNRP1 and shNRP1 + 10 Gy X-rays were allowed to migrate on the Transwell inserts for 12 hrs, and A549 cells without X-ray irradiation acted as the control group. The cells which invaded and migrated to the lower side of the filter were fixed in 4% paraformaldehyde and stained with Giemsa solution. The number of cells that passed through the pores into the lower chamber was counted under a phase-contrast microscope. (D) Microvessel density (MVD) of xenograft tumours in the knockdown (KD), negative control (NC) (magnification, ×200). NRP1 silencing led to a significant decrease in MVD in the KD group.