Table 2. Secondary metabolism gene clusters in A. nidulans.
| No. | Broad designation | Gene name | Gene typea | Actual or predicted productb |
|---|---|---|---|---|
| 1 | AN0016.3 | pes1 | NRPS | |
| 2 | AN0150.3 | mdpG | NR-PKS | monodictyphenone (18), emodin (17),54 xanthones (30–33)66 |
| 3 | AN0523.3 | NR-PKS | ||
| 4 | AN0607.3 | sidC | NRPS | ferricrocin137 |
| 5 | AN1034.3 | afoE | NR-PKS | asperfuranone (15)34 |
| 6 | AN1036.3 | afoG | PR-PKS | asperfuranone (15)34 |
| 7 | AN1242.3 | NRPS | cyclotripeptide | |
| 8 | AN1680.3 | NRPS-like | ||
| 9 | AN1784.3 | PR-PKS | ||
| 10 | AN2032.3 | NR-PKS | ||
| 11 | AN2035.3 | PR-PKS | ||
| 12 | AN2064.3 | NRPS-like | ||
| 13 | AN2545.3 | easA | NRPS | emericellamides (1–5)26 |
| 14 | AN2547.3 | easB | PR-PKS | emericellamides (1–5)26 |
| 15 | AN2621.3 | acvA | NRPS | penicillin138 |
| 16 | AN2924.3 | NRPS-like | ||
| 17 | AN3230.3 | NR-PKS | ||
| 18 | AN3386.3 | NR-PKS | ||
| 19 | AN3396.3 | NRPS-like | ||
| 20 | AN3495.3 | NRPS-like | ||
| 21 | AN3496.3 | NRPS | ||
| 22 | AN3612.3 | PR-PKS | ||
| 23 | AN4827.3 | NRPS-like | ||
| 24 | AN5318.3 | NRPS-like | ||
| 25 | AN6000.3 | aptA | NR-PKS | asperthecin (21)55 |
| 26 | AN6236.3 | sidD | NRPS | siderophore |
| 27 | AN6431.3 | PR-PKS | ||
| 28 | AN6444.3 | NRPS-like | ||
| 29 | AN6448.3 | NR-PKS | ||
| 30 | AN6791.3 | PR-PKS | ||
| 31 | AN7071.3 | NR-PKS | ||
| 32 | AN7084.3 | PKS-like | ||
| 33 | AN7489.3 | PKS-like | ||
| 34 | AN7815.3 | stcJ | FAS subunit alpha | sterigmatocystin139 |
| 35 | AN7825.3 | stcA (pksST) | NR-PKS | sterigmatocystin139 |
| 36 | AN7838.3 | PKS-like | ||
| 37 | AN7884.3 | NRPS | ||
| 38 | AN7909.3 | orsA | NR-PKS | orsellinic acid (22),59,60 F-9775A (19), B (20)54,59 |
| 39 | AN8105.3 | NRPS-like | ||
| 40 | AN8209.3 | wA | NR-PKS | naphthopyrone (YWA1)140 |
| 41 | AN8383.3 | NR-PKS | ||
| 42 | AN8412.3 | apdA | Hybrid | aspyridone A (13), B (14)33 |
| 43 | AN8513.3 | tdiA | NRPS | terrequinone A (9)46 |
| 44 | AN8910.3 | PR-PKS | ||
| 45 | AN9005.3 | PR-PKS | ||
| 46 | AN9226.3 | NRPS | ||
| 47 | AN9244.3 | NRPS | ||
| 48 | AN9291.3 | NRPS-like | ||
| 49 | AN10297.3 | NRPS-like | ||
| 50 | AN10430.3 | NR-PKS | ||
| 51 | AN10486.3 | NRPS-like | ||
| 52 | AN10576.3 | NRPS | ||
| 53 | AN11191.3 | PR-PKS |
a
abbreviations: polyketide synthase (PKS), non ribosomal peptide synthetase (NRPS), PKS–NRPS (Hybrid), fatty acid synthase (FAS), nonreduced polyketide synthase (NR-PKS), partially reduced polyketide synthase (PR-PKS), highly reduced polyketide synthase (HR-PKS)
b
Actual products are highlighted in bold.