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. 2015 Jul 14;7(9):1229–1243. doi: 10.15252/emmm.201404669

Figure 3. Reduced cardiac dysfunction in mice with cardiac LXRα activation in response to pathological pressure overload.

Figure 3

  • A Echocardiographic assessment of percent fractional shortening in mice subjected to 5 weeks of TAC; n = 19 Wt sham, n = 22 LXRα-Tg sham, n = 24 Wt TAC, n = 26 LXRα-Tg TAC. **P < 0.00001 versus Wt sham, *P = 0.0005 versus LXRα-Tg sham, #P = 0.009.
  • B–D Hemodynamic measurements obtained in situ in sham- and TAC-operated mice; n = 6–8/group. (B) Mean arterial pressure (MAP) showed no significant differences. (C) LV end-systolic pressure (LVESP). **P < 0.00001 versus Wt sham, *P = 0.00004 versus LXRα-Tg sham, *P = 0.003. (D) LV end-diastolic pressure (LVEDP). *P = 0.02 versus Wt sham.

Data information: Data are means ± SEM; one-way ANOVA with Bonferroni’s multiple comparison test was used to compare groups.