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. 2015 Jul 14;7(9):1229–1243. doi: 10.15252/emmm.201404669

Figure 7. Knockdown of LXRα increases cellular hypertrophy in cultured cardiomyocytes.

Figure 7

Cells were transfected with Ad-LXRα, si-LXRα, or Ad-cont, in the absence or presence of phenylephrine (PE).
  • A Protein synthesis determined via leucine incorporation, n = 2–4 independent experiments. *P = 0.03 versus Ad-cont, §P = 0.06 versus Ad-cont.
  • B Global O-GlcNAc protein expression with Western blot, GAPDH served as a control.
  • C–F mRNA expression, normalized to 36b4, n = 6 per condition, except n = 5 for si-LXRα control. Anp: *P = 0.009 versus Ad-cont, #P = 0.004, ##P = 0.009; Bnp: *P = 0.004 versus Ad-cont, **P = 0.002 versus Ad-cont; Acta1: *P = 0.002 versus Ad-cont, §P = 0.06 versus Ad-cont, #P = 0.02; Rcan1: *P = 0.03 versus Ad-cont, **P = 0.004 versus Ad-cont, #P = 0.004.

Data information: Data are means ± SEM and are reported as fold change with respect to control group; Kruskal–Wallis test followed by Mann–Whitney U-test was used for group comparisons. Source data are available online for this figure.