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. Author manuscript; available in PMC: 2015 Sep 14.
Published in final edited form as: Clin Microbiol Infect. 2013 Mar 7;19(5):E222–E229. doi: 10.1111/1469-0691.12134

Figure 3. Insertion-deletion (indel) characteristics of M proteins belonging to the same emm-type.

Figure 3

Intra-emm-type alignments that include 900 M protein sequences of 80 emm-types reveal 408 indels. More than half of the indels (n=224; 55%) are located in the CRR (C Repeat Region). The remaining indels are equally distributed between regions corresponding to the 50 amino-terminus proximal residues (n=85; 21%; emm-type determinant) and from residue 51 to the beginning of the CRR (n=99; 24%; sub-N-terminal, central region). The number of indels having a heptad periodicity increases from the amino-terminal (36% of indels) to the carboxy-terminal (CRR; 99% of indels) regions of M proteins, whereas half (50%) of the indels from the central region of M protein involve multiples of seven residues.