Table 1.

Candidate genes involved in renal aging

Gene	Analyzed phenotype	Possible function in renal aging
CUBN	Albuminuria	Cubilin functions as an endocytic receptor of albumin. A defect in this tubular reabsorption leads to albuminuria.
UMOD	CKD, eGFR decline	UMOD influences NaCl reabsorption; overexpression leads to salt-sensitive hypertension.
		Overexpression also causes age-dependent lesions; tubular casts and tubular dilatation.
SHROOM3	CKD	A defect in the actin-binding domain of SHROOM3 results in impairment of the glomerular filtration barrier leading to albuminuria and glomerulosclerosis.
		Increased SHROOM3 expression is associated with fibrosis.
Far2	Mesangial matrix expansion	Overexpression of Far2 leads to upregulation of PAF and TGFβ; profibrotic factors.
Wisp2	Tertiary lymphoid organs	Wisp2 is part of the Wnt signaling pathway and linked to aging-related inflammation
Esrrg	Glomerular lipoprotein depositsTertiary lymphoid organs	This orphan nuclear receptor influences lipid metabolism, is involved in cardiovascular disease, and associated with altered blood pressure.
		Exact mechanism unknown.