Table 2.
Genomewide association studies associated genes shared among 3 or more age-related disease categories
| Gene ID | Gene name | Function |
|---|---|---|
| 3118 | Major histocompatibility complex, class II, DQ alpha 2 | MHC |
| 3119* | Major histocompatibility complex, class II, DQ beta 1 | MHC |
| 3120 | Major histocompatibility complex, class II, DQ beta 2 | MHC |
| 3122* | Major histocompatibility complex, class II, DR alpha | MHC |
| 3123 | Major histocompatibility complex, class II, DR beta 4 | MHC |
| 100507714 | HLA class II histocompatibility antigen, DQ beta 1 chain-like | MHC |
| 100507709 | HLA class II histocompatibility antigen, DRB1-7 beta chain-like | MHC |
| 101060835* | HLA class II histocompatibility antigen, DQ beta 1 chain-like | MHC |
| 100509457 | HLA class II histocompatibility antigen, DQ alpha 1 chain-like | MHC |
| 3117 | Major histocompatibility complex, class II, DQ alpha 1 | MHC |
| 56244 | Butyrophilin-like 2 (MHC class II associated) | MHC |
| 84166 | NLR family, CARD domain containing 5 | MHC Regulation |
| 7940 | Leukocyte specific transcript 1 | Immune Regulation |
| 80740 | Lymphocyte antigen 6 complex, locus G6C | Immune Regulation |
| 80741 | Lymphocyte antigen 6 complex, locus G5C | Immune Regulation |
| 1379 | Complement component (3b/4b) receptor 1-like | Immune Regulation |
| 1460 | Lymphocyte antigen 6 complex, locus G5B | Immune Regulation |
| 199 | Allograft inflammatory factor 1 | Immune Regulation |
| 259197 | Natural cytotoxicity triggering receptor 3 | Immune Regulation |
| 259215 | Lymphocyte antigen 6 complex, locus G6F; | Immune Regulation |
| 5819 | Poliovirus receptor-related 2 | Immune Regulation |
| 58496 | Lymphocyte antigen 6 complex, locus G5B | Immune Regulation |
| 58530 | Lymphocyte antigen 6 complex, locus G6F | Immune Regulation |
| 6934 | Transcription factor 7-like 2 (T-cell specific) | Immune Regulation |
| 10665 | Erythroid Differentiation-Related Factor 1 | Immune Regulation |
| 28 | ABO blood group | Immune Regulation |
| 5089 | Pre-B-cell leukemia homeobox 2 | Immune Regulation |
| 63940 | G-protein signaling modulator 3 | Immune Regulation |
| 177 | Advanced glycosylation end product specific receptor | Inflammation |
| 4050 | Lymphotoxin beta (TNF superfamily, member 3) | Inflammation |
| 10019 | SH2B adaptor protein 3 | Inflammation |
| 10554 | Lysophosphatidic acid acyltransferase, alpha | Inflammation/Lipid Signaling |
| 64116 | Solute carrier family 39 (zinc transporter), member 8 | Other |
| 1029† | Cyclin-dependent kinase inhibitor 2A (p16) | Cell Cycle Regulation (p16 INK4a) |
| 1030 | Cyclin-dependent kinase inhibitor 2B (p15) | Cell Cycle Regulation |
| 2262 | Glypican 5 | Cell Signaling |
| 4855 | Notch homolog 4 | Cell Signaling |
| 6311 | Ataxin 2 | Cell Signaling/Intracellular Trafficking |
| 57827 | Apoliprotein M | Cholesterol Metabolism/Cell Signaling |
| 60526 | Apolipoprotein B | Cholesterol Metabolism/Other |
| 1071 | Cholesteryl ester transfer protein, plasma | Cholesterol Metabolism |
| 341 | Apolipoprotein C-I | Cholesterol Metabolism |
| 348 | Apolipoprotein E | Cholesterol Metabolism |
| 55937 | Apolipoprotein M | Cholesterol Metabolism |
| 217 | Aldehyde dehydrogenase 2 family | Metabolism |
| 3990 | Lipase, hepatic | Metabolism |
| 6048 | Ring finger protein 5 | Histone modification |
| 6838 | Surfeit 6 | Nucleolar Protein/Ribosome Biogenesis |
| 79068 | Fat mass and obesity associated (FTO) | mRNA Regulation |
| 10452† | TOM40 | Mitochondrial Protein Import (APOE LOCUS) |
Gene ID, name, and generic function, based on NCBI gene description, are indicated.
*
—Genes associated with all five disease categories.
†
—Genes previously reported to associate with multiple age-related diseases.