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. 2015 Jul 29;14(5):896–906. doi: 10.1111/acel.12376

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© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig 1 — Adult Neuronal CycD/Cdk4 reduces lifespan. Lifespan analysis of flies expressing the indicated genes using the pan-neuronal driver, ELAV-GeneSwitch. (A) Adult females expressing ELAV-GeneSwitch and CycD/Cdk4 (EtOH vs. RU P = 0, EtOH MT vs. RU + MT P = 0.133). (B) ELAV-GeneSwitch; CycD RNAi (EtOH vs. RU P = 0, EtOH MT vs. RU + MT P = 0.788). (C) ELAV-GeneSwitch; Tfam RNAi (EtOH vs. RU P = 0, EtOH MT vs. RU + MT P = 0.0976). (D) ELAV-GeneSwitch; CycD/Cdk4 + Tfam RNAi (EtOH vs. RU P = 0, EtOH MT vs. RU + MT P = 0.0101). EtOH: ethanol-fed control. 50 RU: 50 ug mL⁻¹ RU-486 GeneSwitch induction. MT, MitoTEMPO.