Table 1.
HLA-associations with sarcoidosis and its subphenotypes (LS: Löfgren syndrome; EPM: extra-pulmonary manifestation)
| Locus | Allele | Phenotype | OR | Reference reporting association | N with phenotype | N without phenotype | N controls | Ethnicity/ Nation |
|---|---|---|---|---|---|---|---|---|
| HLA-B | *51 | LS | 11.11 | 7 | 22 | 122 | China | |
| DQB1 | *0201 | LS | 12.50 | 8 | 47 | 218 | Dutch | |
| *0201 | LS | 17.40 | 8 | 47 | 92 | Dutch | ||
| DQB1 | *0503/4 | Sarcoidosis | 2.55 | 8 | 340 | 354 | UK | |
| *0503/4 | Lung sarcoidosis | 2.80 | 8 | 233 | 354 | UK | ||
| *0503/4 | Lung sarcoidosis | 4.40 | 8 | 78 | 218 | Dutch | ||
| DRB1 | *01 | Resolving | 2.44 | 9 | 325 | 399 | Sweden | |
| *11 | Sarcoidosis | 6.25 | 7 | 131 | 122 | China | ||
| *11 | EPM | 0.36 | 10 | 39 | 52 | Turkey | ||
| *1101 | Sarcoidosis | 1.98 | 11 | 474 | 474 | Mixed US | ||
| *1101 | Sarcoidosis | 1.69 | 12 | 1277 | 1467 | African Americans | ||
| *1101 | Persistent | 1.41 | 12 | 624 | 308 | African Americans | ||
| *12 | Sarcoidosis | 3.71 | 8 | 340 | 354 | UK | ||
| *12 | Lung sarcoidosis | 4.20 | 8 | 233 | 354 | UK | ||
| *12 | Lung sarcoidosis | 5.30 | 8 | 37 | 168 | Japan | ||
| *1201 | Sarcoidosis | 2.13 | 11 | 474 | 474 | Mixed US | ||
| *1201 | Sarcoidosis | 2.06 | 12 | 1277 | 1467 | African Americans | ||
| *14 | Sarcoidosis | 1.79 | 9 | 754 | 1366 | Sweden | ||
| *1401/2 | Sarcoidosis | 2.54 | 8 | 340 | 354 | UK | ||
| *1401/2 | Lung sarcoidosis | 2.70 | 8 | 233 | 354 | UK | ||
| *15 | Sarcoidosis | 2.37 | 10 | 91 | 145 | Turkey | ||
| *1501 | Sarcoidosis | 1.70 | 11 | 474 | 474 | Mixed US | ||
| *1501 | Sarcoidosis | 1.67 | 13 | 188 | 150 | Finland | ||
| *03 | Resolving in LS | 79.98 | 14 | 223 | 45 | Sweden | ||
| *03 | LS | 12.50 | 8 | 47 | 218 | Dutch | ||
| *03 | LS | 18.60 | 8 | 47 | 92 | Dutch | ||
| *03 | Sarcoidosis | 1.91 | 9 | 754 | 1366 | Sweden | ||
| *03 | Resolving | 5.42 | 9 | 325 | 1366 | Sweden | ||
| *03 | Resolving | 2.22 | 9 | 325 | 399 | Sweden | ||
| *03 | Löfgren | 6.71 | 9 | 302 | 1366 | Sweden | ||
| *03 | Sarcoid arthritis | 3.17 | 15 | 39 | 544 | Iceland | ||
| *0301 | Resolving | 2.22 | 13 | 90 | 98 | Finland | ||
| *0301 | Sarcoidosis | 0.56 | 12 | 1277 | 1467 | African Americans | ||
| *0302 | Resolving | 1.92 | 12 | 308 | 624 | African Americans | ||
| *04 | EPM in non-LS | 2.35 | 16 | 257 | 360 | Sweden | ||
| *04 | Sarcoid arthritis | 0.27 | 15 | 39 | 544 | Iceland | ||
| *0803 | Sarcoidosis | 2.43 | 17 | 237 | 287 | Japan |