Table 2.
Adjusted odds ratios in complete sample (training and validation samples combined) for multivariable logistic regression and ordinal risk index models, National Birth Defects Prevention Study, 1997–2007
| Variable | Adjusted odds ratio (95% CI) | ||
|---|---|---|---|
|
| |||
| Spina bifida | Anencephaly | Anencephaly + spina bifida | |
| Multivariable models: | |||
| Family history of NTDsa | 6.93 (3.84–12.50) | 8.36 (4.04–17.30) | 7.17 (4.24–12.10) |
| Hispanic ethnicity | 1.54 (1.30–1.82) | 2.17 (1.73–2.71) | 1.67 (1.45–1.93) |
| Obesity | 1.77 (1.49–2.11) | - | 1.56 (1.35–1.81) |
| Anticonvulsant useb | 2.37 (1.31–4.28) | - | 2.29 (1.37–3.82) |
| Low dietary folate intakec | 1.22 (1.03–1.44) | 1.57 (1.25–1.98) | 1.33 (1.16–1.53) |
| Female infant sex | - | 1.26 (1.02–1.56) | - |
| Ordinal risk index model: | |||
| Ordinal risk index scored | 1.56 (1.41–1.72) | 1.62 (1.41–1.85) | 1.57 (1.45–1.71) |
a
In first or second-degree relative
b
During the month before pregnancy and the first month of pregnancy (B1-P1)
c
Based on the lowest quartile of dietary folate equivalent level in controls
d
Unadjusted odds ratio for each one unit increase in ordinal risk index