Table 3.

Insulin and C-peptide response to glucose, arginine, glucose-potentiated arginine and SUITO Score at 3, 6, 12 and 24 months posttransplant. (A) Intravenous glucose tolerance test glucose (IVGTT) Glucose disposal and insulin and C-peptide secretion kinetics after stimulation with glucose. Incremental first-phase AUC and percentage over basal (means of the values from 2–10 minus basal value, divided by the basal value and expressed as percent). Kg was calculated based on the values for 10–20 min post glucose injection. (B) Arginine alone at 5mM glucose (ARG). Basal levels, incremental AUC from 2 to 5 min data and percentage of basal was calculated for plasma insulin and C-peptide after arginine stimulation. (C) Glucose potentiation of arginine-induced secretion (GPAIS) at 15 mM glucose. Basal levels, ncremental AUC from 2 to 5 min data and percentage of basal was calculated for plasma insulin and C-peptide after arginine stimulation at hyperglycemia

N = 1	3 months n = 27			6 months n = 19			12 months n = 27			Nondiabetic control subjects n = 10^*
Section A: IVGTT	Basal	Incr. AUC	% Baseline	Basal	Incr. AUC	% Baseline	Basal	Incr. AUC	% Baseline	Basal	Incr. AUC	% Baseline

Insulin	59.2 ±11.9	945.8 ±172	244 ±39^*	41.2±7	955 ±154.2	337±61^*	39.1 ±4.5	915.6±209	300.8 ±59^*	16±4	1448 ±243	1036 ±294
C-peptide	0.4 ±0.03	2.11 ±0.31^*	53 ±8.4^*	1.42 ±0.4^**	2.45 ±0.4^*	65±11^*	0.42 ±0.1	1.89 ±0.43^*	50 ± 11 ^*	0.5 ±0.1	7.3± 1.2	160±71
Kg	1.33 + 0.1			1.38 + 0.1					1.4 + 0.2	1.4 + 0.2

		n = 27			N = 19			N = 27			n = 10

Section B: ARG

Insulin	63.3 ±11.9	538.7 ±60	257 ±29^**	70.8±19	693.8 ±124	288.5 ±43	52.6±6^***	516.9±102	247 ±49	23±4	708 ±261	446 ±106
C-peptide	0.4 ±0.1	1 ±0.12^*	58±6^***	0.54 ±0.1	1.36±0.2^**	60.7 ±9^**	0.5 ±0.1	1.12±0.2^**	56±5^***	0.5 ±0.1	2.7 ±0.6	125 ±29

	n = 13	n = 8	n = 13	n = 10

Section C: GPAIS

Insulin	150.8 ±48	2138±291^**	1385 ±333^*	116±36	2722 ±587^**	1794±343^***	147.3 ±47	3308 ±942^*	746.8 ±239	168±27	6817±1527	4552 ±623
C-peptide	0.6 ±0.1	7.0±1.2^***	334 ±34^*	0.7 ±0.2	10.1 ±2^***	368 ±78^***	0.7 ±0.2	6.0±2.6^***	476 ±166^**	0.5 ±0.1	21.1 ±2.7	912 ±138

	N = 27	N = 19	N =27	N = 10

Section D: SUITO	3 months			6 months			12 months		Nondiabetic control subjects

score	49.2 + 6.0			60.6±7.3			67.5±15.0		132.5 + 93.5

Nondiabetic subjects were used as a control group. Data are expressed as mean ± SEM.

p < 0.001 for this time point to nondiabetic controls.

^**

p < 0.05 for this time point to nondiabetic controls.

^***

p < 0.01 for this time point to nondiabetic controls.