Skip to main content
. 2015 Sep 14;10(9):e0136914. doi: 10.1371/journal.pone.0136914

Fig 1. Scheme of the arginase pathway and the arginine decarboxylase pathway.

Fig 1

In Bacillus subtilis, the first reaction of the arginase pathway, the formation of ornithine (Orn), is catalyzed by arginase (rocF). RocD, an ornithine aminotransferase, utilizes ornithine to form glutamate semialdehyde (GSA) or pyrroline-5-carboxylate (P5C). P5C is the substrate of RocA, a pyrroline-5-carboxylate dehydrogenase, which produces glutamate (Glu). In Yersinia pestis, an arginine decarboxylase (speA) forms agmatine (Agma). Agma is further degraded to N-carbamoylputrescine (CP) and putrescine (Put) by aguA, aguB, and speB. The genome of Mtb includes homologues for the arginase pathway (rocD, rocA) and the arginine decarboxylase pathway (speA / adi).