Table 1. List of the significant associations (p ≤ 0.05) with slow and non-progression.
Alleles, allele frequencies (AF), positional data and genetic modes are provided with the results of the statistical inferences. Opposite signs for the β coefficients are required for an association to be replicated in the GRIV (non-progression) and ACS cohorts (time to AIDS93).
| SNP | Alleles Ref/Alt | AF (Alt) | Chromosome/position | Mode | β (GRIV) | p (GRIV) | β (ACS) | p (ACS) | Allele associated with non-progression | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 732563 | T | C | 53% | 8 | 23,488,013 | additive | -0.23 | 0.029 | 0.21 | 0.029 | T |
| 732563 | T | C | 53% | 8 | 23,488,013 | recessive | -0.41 | 0.024 | 0.40 | 0.007 | T |
| 2205418 | T | C | 12% | 21 | 28,657,885 | recessive | -2.24 | 0.038 | 2.81 | 1.5·10–4 | T |
| 2241335 | C | T | 45% | 7 | 134,294,616 | dominant | 0.44 | 0.015 | -0.34 | 0.034 | T |
| 2242229 | G | T | 78% | 17 | 75,246,420 | recessive | 0.49 | 0.003 | -0.33 | 0.025 | T |
| 2921446 | C | A | 66% | 10 | 72,691,727 | dominant | 0.53 | 0.037 | -0.48 | 0.024 | A |
| 3130350 | G | T | 7% | 6 | 30,360,062 | additive | -0.66 | 0.019 | 0.51 | 0.001 | G |
| 3130350 | G | T | 7% | 6 | 30,360,062 | dominant | -0.73 | 0.015 | 0.42 | 0.010 | G |
| 3130501 | A | G | 77% | 6 | 31,168,676 | dominant | -0.78 | 0.021 | 0.81 | 0.038 | A |
| 3749971 * | G | A | 6% | 6 | 29,374,998 | dominant | -0.67 | 0.036 | 0.37 | 0.031 | G |
| 4714580 | A | G | 83% | 6 | 42,206,820 | recessive | -0.32 | 0.049 | 0.33 | 0.045 | A |
(*) Note that rs3749971 is in linkage disequilibrium with rs3130350 and is therefore not considered an independent finding in our statistics (see text).