Table 2. List of SNP/gene pairs associated with AIDS progression.
The genetic association is linked back to its association with gene expression levels to provide an association between transcription levels (we use the word ‘regulation’ for convenience’s sake) and AIDS progression.
| SNP | Chromosome | Gene | Gene function | Association with non-progression |
|---|---|---|---|---|
| 732563 | 8 | ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | Down-regulation |
| 2205418 | 21 | CCT8 | chaperonin containing TCP1, subunit 8 (theta) | Down-regulation |
| 2241335 | 7 | SLC35B4 | solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 | Up-regulation |
| 2242229 | 17 | MRPS7 | mitochondrial ribosomal protein S7 | Up-regulation |
| 2921446 | 10 | DNAJB12 | DnaJ (Hsp40) homolog, subfamily B, member 12 | Down-regulation |
| 3749971/3130350 | 6 | ZFP57 | ZFP57 zinc finger protein | Down-regulation |
| 3130501 | 6 | HCG27 | HLA complex group 27 (non-protein coding) | Down-regulation |
| 4714580 | 6 | GUCA1B | guanylate cyclase activator 1B (retina) | Down-regulation |
| 4714580 | 6 | MRPS10 | mitochondrial ribosomal protein S10 | Down-regulation |
(*) Note that rs3749971 is in linkage disequilibrium with rs3130350 and is therefore not considered an independent finding (see text).