Table 3. Univariate and multivariate analyses of clinical variables and quantitative metabolic parameters for disease-free survival.
Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |
Age (years) <45 vs. ≥45 | 1.030 | 0.6–4.2 | 0.310 | |||
Primary tumor SUVmax >12.3 vs. ≤12.3 | 0.673 | 0.5–4.0 | 0.412 | |||
Primary tumor MTV >63.7 cm3 vs. ≤63.7 cm3 | 2.172 | 0.8–5.6 | 0.141 | |||
Primary tumor TLG >411.9 vs. ≤411.9 | 2.294 | 0.8–5.8 | 0.130 | |||
Nodal SUVmax >4.7 vs. ≤4.7 | 7.592 | 1.8–34.8 | 0.006 | 4.158 | 1.1–22.7 | 0.041 |
Nodal MTV >10.3 cm3 vs. ≤10.3 cm3 | 6.015 | 1.3–9.2 | 0.014 | |||
Nodal TLG >32.9 vs. ≤32.9 | 6.266 | 1.3–9.4 | 0.012 | |||
FIGO stage >IIB vs. IIB | 1.695 | 0.7–5.2 | 0.193 | |||
Tumor size ≥4 cm vs. <4 cm | 0.811 | 0.5–5.1 | 0.368 | |||
Paraaortic node metastases | 5.393 | 1.2–8.5 | 0.020 | |||
Post-treatment response PR or PD vs. CR | 13.289 | 2.4–17.0 | <0.001 | 7.162 | 1.5–11.3 | 0.007 |
SUVmax = maximum standardized uptake value; MTV = whole-body metabolic tumor volume; TLG = total lesion glycolysis; FIGO = International Federation of Gynecology and Obstetrics; CR = complete response; PR = partial response; PD = progressive disease; HR = hazard ratio; CI = confidence interval.