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. 2015 Sep 15;26(18):3178–3189. doi: 10.1091/mbc.E15-04-0209

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© 2015 Gao et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — TRAIL induces the expression of the proinflammatory cytokines IL-1β, IL-6, and TNF-α in macrophages. (A) Serum from TRAIL-stimulated mice was analyzed for IL-1β, IL-6, and TNF-α using ELISA. The expression of these cytokines was detected in peritoneal macrophages from TRAIL-treated mice by q-PCR. Data are shown as mean ± SD (n = 5). (B) q-PCR analysis of IL-1β, IL-6, and TNF-α in mouse peritoneal macrophages after stimulation with rsTRAIL for the indicated times. The mRNA levels were normalized relative to the expression of β-actin. The supernatant from TRAIL-stimulated macrophages was analyzed using ELISA. Data are shown as mean ± SD (n = 5). (C) q-PCR analysis of these cytokines in human monocyte-derived macrophages after challenge with rsTRAIL. Data are mean ± SD (n = 3) of three independent experiments. *, p < 0.05; **, p < 0.01 compared with control.