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. 2015 Sep 15;26(18):3178–3189. doi: 10.1091/mbc.E15-04-0209

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© 2015 Gao et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — miR-146a was activated by TRAIL administration and negatively regulated the expression of IL-1β, IL-6, and TNF-α in macrophages. (A) q-PCR analysis of miR-146a in peritoneal macrophages from TRAIL-stimulated mice. Data are shown as mean ± SD (n = 5). (B) q-PCR analysis of miR-146a in mouse peritoneal macrophages treated with rsTRAIL. The expression of miR-146a was normalized relative to the expression of U6. (C) q-PCR analysis of miR-146a in human monocyte-derived macrophages stimulated with rsTRAIL. (D) Macrophages were transfected with miR-146a mimics and inhibitor for 48 h following rsTRAIL treatment for 3 h, and the proinflammatory cytokine expression was analyzed by q-PCR. Data are mean ± SD (n = 3) of three independent experiments. *, p < 0.05; **, p < 0.01 compared with control. ^##, p < 0.01; ^#, p < 0.05 compared with TRAIL-treated and control mimics/inhibitor-transfected cells.