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. 2015 Sep 15;26(18):3178–3189. doi: 10.1091/mbc.E15-04-0209

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© 2015 Gao et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — MiR-146a expression was regulated by histone acetylation in macrophages. (A) q-PCR assay of miR-146a expression in peritoneal macrophages treated with rsTRAIL for 6 h, TSA for 12 h, or the combination of both. The miR-146a levels were normalized relative to U6. (B) ChIP assay of histone H3 acetylation and p65 subunit binding to the two NF-κB binding sites in the miR-146a promoter in macrophages with the same treatments as in A. (C) q-PCR assay of HDAC1–11 in TRAIL-stimulated macrophages. Data are mean ± SD (n = 3) of three independent experiments. **, p < 0.01; *, p < 0.05 compared with control.