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. 2015 Sep 14;11(9):e1005161. doi: 10.1371/journal.ppat.1005161

Fig 2. Intrinsic MyD88 signaling in CD8 T cells is required for vaccine immunity.

Fig 2

(A & B) CD4+ T-cell depleted naïve mice were vaccinated with live (A) or heat-killed (B) #55 yeast (B). Vaccinated mice were challenged with virulent #26199 yeast, lungs were harvested for CFU analysis on indicated days, and data are shown in whisker plots (A & B; N = 7–14 mice/group). Lungs were harvested 4 days post-challenge to enumerate percentage (C) and total number of cytokine-producing CD8+ T cells (D) by flow cytometry. CD4+ T cells were depleted throughout experiment. Values are the mean ± SD of 5 mice/group. *p≤0.05, **p≤0.01, ***p≤0.001 and ****p≤0.0001. Data is representative of 2 independent experiments.