Table 1. Functional groupings of significantly dysregulated proteins in msDNA mutants.

Proteins reduced in abundance, and proteins increased in abundance in msDNA mutants as determined by clusters of orthologous grouping [71].

COG grouping	# of proteins
Proteins in reduced abundance mutants lacking msDNA relative to WT
amino acid transport and metabolism	32
energy production and conversion	27
carbohydrate transport and metabolism	14
cell wall/membrane/envelope biogenesis	9
coenzyme transport and metabolism	8
secondary metabolite transport, biosynthesis, catabolism	8
signal transduction	6
nucleotide transport and metabolism	5
transcription	5
inorganic ion transport and metabolism	4
post-translational modification, protein turnover, chaperone	3
intracellular trafficking, secretion, vesicular transport	2
cell cycle control, chromosome partitioning, cell division	2
cell motility	1
lipid transport and metabolism	1
general or unknown function	43
Proteins in increased abundance in mutants lacking msDNA relative to WT
cell motility	8
translation ribosomal structure, and biogenesis	8
energy production and conversion	5
inorganic ion transport and metabolism	5
amino acid transport and metabolism	4
cell wall/membrane/envelope biogenesis	4
signal transduction mechanisms	3
transcription	3
coenzyme, lipid, nucleotide transport and metabolism	3
carbohydrate transport and metabolism	2
post-translational modification, protein turnover, chaperone	2
replication, recombination, and repair	2
intracellular trafficking, secretion, vesicular transport	1
general or unknown function	18