. 2015 Sep 14;9(9):e0004054. doi: 10.1371/journal.pntd.0004054

Table 4. Selected proteins from S1 Table that contain 1–2 transmembrane domains, a significant non-cytoplasmic portion, >75% homology to either W. bancrofti, or O. volvulus, and <40% homology to humans.

		H. sapiens		W. bancrofti		O. volvulus		L. loa		D. immitis
Pub Locus		%Ident	Query cov.	%Ident	Query Cov	%Ident	Query Cov	%Ident	Query Cov	%Ident	Query Cov	Non-cytoplasmic domain	Transmembrane domain
Cell Adhesion
^*Bm1_39630	Immunoglobulin I-set domain containing protein	28	45–1170	97	628–1171	87	26–1171	89	1–1171	82	1–1171	19–1120	1
^*Bm1_02820	EGF-like domain containing protein	35	53–206	96	1–269	82	3–269	89	62–269	79	2–269	1–225	1
Cell Signaling
^*Bm1_30585	Tyrosine-protein kinase abl-1.-related	24	212–281	95	10–281	79	10–281	83	10–281	84	10–281	19–135	1
^*Bm1_19395	Protein kinase domain containing protein	34	15–1280	98	1–681	92	1–1280	95	1–1280	93	1–1280	1–942	1
^*Bm1_38285	Ser/Thr protein phosphatase family protein	40	22–287	95	9–293	79	2–293	88	9–293	79	1–290	41–293	1
Chaperone/HSP
^*Bm1_15660	DnaJ domain containing protein	27	25–835	91	1–839	77	3–839	85	11–839	80	1–839	18–220	1
^*Bm1_22450	hemimethylated DNA binding domain containing protein	25	34–112	97	29–119	95	29–119	97	29–119	91	28–119	1–125	1
Glycosylation/glucuronidation
^#Bm1_44655	Fukutin.-related	31	138–364	96	1–362	73	1–364	85	1–364	75	1–364	28–364	1
^#Bm1_13480	UDP-glucoronosyl and UDP-glucosyl transferase family protein	27	35–509	95	1–425	29	214–293	81	1–423	72	155–502	1–486	1
Miscellaneous
^#Bm1_49590	CG3054-PA-related	28	97–260	81	1–242	69	1–260	63	1–262	67	1–254	1–51, 101–265	2
^*Bm1_10500	AMOP domain containing protein	26	652–932	98	679–1377	92	1–1513	94	1–1513	90	609–1513	23–1322	1
^#Bm1_48010	EGF-like domain containing protein	36	10–395	91	19–338	66	6–560	74	6–556	64	6–546	1–430	1
Proteases
^#Bm1_38300	Peptidase family M1 containing protein	28	136–586	90	90–819	67	1–819	74	1–819	70	1–819	81–1061	1
^*Bm1_11005	MGC84665 protein-related	38	2–98	95	1–96	80	1–98	91	1–98	90	1–40	1–16,76–169	1
^*Bm1_53050	Reprolysin	32	153–753	91	96–845	77	1–839	79	1–839	77	1–843	1–607	1
Possible Proteases
^#Bm1_00205	ShTK domain containing protein	27	54–161	80	142–229	52	70–227	46	126–264	55	110–264	26–264	1
Protease Inhibitors
^#Bm1_09775	serpin, putative	29	26–388	75	84–375	52	29–390	54	1–391	52	1–391	17–391	1
Hypothetical Proteins
^*Bm1_52210	hypothetical protein	29	238–350	97	53–433	85	1–431	87	15–432	84	1–430	1–369	1
^*Bm1_57335	Conserved hypothetical protein, putative	31	114–236	96	1–246	89	1–246	91	1–246	87	1–246	29–211	2
^$ ^&Bm1_20460	hypothetical protein	30	103–147	24	94–147	82	1–191	86	1–191	85	1–191	143–147	2
^#Bm1_45100	hypothetical protein	29	330–414	85	118–727	60	75–727	67	81–696	49	271–727	285–727	1
^* ^&Bm1_07875	CONSERVED HYPOTHETICAL PROTEIN	31	84–225	99	142–231	85	53–231	90	42–231	90	41–231	1–56.	1
^*Bm1_17550	hypothetical protein	33	63–121	87	77–129	82	82–125	77	77–129	86	82–125	1–61.	1
^#Bm1_07845	hypothetical protein	28	24–108	89	1–210	64	1–210	75	1–210	72	60–210	53–210	1
^{^}Bm1_17255	hypothetical protein	21	93–246	87	17–251	78	28–251	73	13–251	75	28–251	36–251	1
^*Bm1_20325	Hypothetical protein-conserved	37	2–215	96	1–487	89	1–487	91	1–487	89	1–485	1–194	1
^#Bm1_46230	hypothetical protein	29	184–256	91	24–278	62	1–278	65	18–278	31	161–281	121–289	1

Non-cytoplasmic domain refers to the span of amino acids predicted to be non-cytoplasmic.

^# >75% homology to W. bancrofti,

^$ >75% homology to O. volvulus,

^{^} >75%homology to both W. bancrofti and O. volvulus,

*>75% homology to W. bancrofti, O. volvulus, L. loa, and D. immitis.

^&Previously found in the excretory/secretory products of adult female B. malayi