Table 2. Cytotoxicity of 1, 2, 3, 4 and 5 against PC-3, Z-138 and JURKAT cancer cell lines and HMLE, MCF 10A, 1BR3G and CCD-18Co non malignant cells.
| IC50 (μM) a | Hemolysis (%) b | |||||||
|---|---|---|---|---|---|---|---|---|
| Cell line | ||||||||
| Compound | PC-3 | Z-138 | JURKAT | HMLE | MCF-10A | 1BR3G | CCD-18Co | |
| 1 | 8.5 ± 1.4 | 4.8 ± 1.2 | 15.1 ± 3.1 | 6.4 ± 04 | 18.8 ± 2.9 | 12.7 ± 1.6 | 27.0 ± 4.4 | 0 |
| 2 | 3.8 ± 0.2 | 4.4 ± 0.3 | 7.2 ± 1.9 | 7.0 ± 0.3 | 6.5 ± 1.3 | 7.5 ± 0.5 | 20.7 ± 0.3 | 0 |
| 3 | 35.0 ± 4.2 | 16.5 ± 1.4 | >100 | 32.5 ± 3.8 | 39.7 ± 2.9 | 45.0 ± 1.0 | >100 | 0 |
| 4 | >100 | 23.1 ± 1.8 | >100 | 47.7 ± 4.5 | >100 | 78.0 ± 8.5 | >100 | 0 |
| 5 | 7.7 ± 0.3 | 2.9 ± 0.4 | 5.4 ± 1.3 | 6.1 ± 0.1 | 23.8 ± 1.3 | 18.0 ± 4.2 | 53.5 ± 3.5 | 0 |
a The IC50 values were determined by the MTT assay after 48 h of treatment. Data represents the mean ± SD of at least three independent experiments made in triplicates.
b Percentage of hemolysis at 100 μM.