Fig 4. LCN2 induces foam cell formation.

Foam cell formation is illustrated by the uptake of Dil-labelled oxLDL (10 μg/mL) for 4 hours. Murine primary BMDM were pre-stimulated with LCN2 (0.5 μg/mL) for 24 hours. Foam cell formation is given as percentage of Dil-positive cells per high power field. Representative pictures are shown. Scale bars = 200 μm. Inserts show a higher magnification of the pictures. Scale bars in insert = 50 μm. *P<0.05 vs. control, n = 6 replicated experiments.