Table 2. Mortality rate ratio (MRR) of cancer mortality after cancer diagnosis for current antidepressant (AD) user a and former AD user b at time of cancer diagnosis.
| AD treatment before diagnosis | Population | Person years (PYs) | No. of deaths | Mortality/ 100 PYs | Crude MRR | Adjusted c MRR (95%CI) | Adjusted d MRR (95%CI) |
|---|---|---|---|---|---|---|---|
| 1-year mortality | |||||||
| No e | 168,551 | 130,809 | 43,631 | 33.4 | Ref | Ref | Ref |
| Current user a | 4,304 | 2,539 | 2,138 | 84.2 | 1.75 | 1.31 (1.28; 1.34) | 1.32 (1.29; 1.35) |
| Former user b | 2,331 | 1,610 | 872 | 54.2 | 1.21 | 1.05 (1.01; 1.08) | 1.07 (1.03; 1.11) |
| Conditional 5-year mortality if patients survived the first year after cancer diagnosis | |||||||
| No e | 105,458 | 236,283 | 23,799 | 10.1 | Ref | Ref | Ref |
| Current user a | 1,783 | 3,735 | 598 | 16.0 | 1.40 | 1.19 (1.15; 1.24) | 1.22 (1.17; 1.26) |
| Former user b | 1,226 | 2,601 | 386 | 14.8 | 1.10 | 1.02 (0.97; 1.08) | 1.05 (1.00; 1.11) |
a Current AD users refers to cancer patients who redeemed an AD prescription within 4 months before the cancer diagnosis.
b Former AD users refers to cancer patients who redeemed the last AD prescription more than 4 months before the cancer diagnosis.
c Adjusted for sex, age at time of diagnosis (5-year interval), Charlson comorbidity index (0, 1–2, 3+), marital status (married or cohabiting, living alone), education (low, medium, high), and calendar year (2003–2004, 2005–2007, 2008–2010).
d Adjusted for cancer stage at time of diagnosis (local, regional, distant, and unknown) besides the factors included in the analysis.
e The reference refers to cancer patients who had no AD prescription in the 3 years before cancer diagnosis.