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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Transl Res. 2015 Mar 16;166(4):384–398. doi: 10.1016/j.trsl.2015.03.002

Figure 6.

Figure 6

STAT3 inhibitor blocked the effect of CLCF1 and FSGS serum on Palb. Isolated rat glomeruli were pre-incubated with STAT3 inhibitor Stattic (0.001–1µM) for 15 minutes followed by addition of CLCF1 (10ng/mL). In separate experiments, glomeruli were pre-incubated with Stattic (0.1 or 1µM) for 15 minutes followed by FSGS serum (20µL/mL) for 15 minutes at 37°C. Pre-treatment of glomeruli with Stattic (0.05–1µM) significantly blocked the effect of CLCF1 (P<0.001 vs.CLCF1 alone). Pre-incubation with Stattic (1µM) blocked the effect of FSGS serum on Palb. (#, P<0.001 vs. FSGS alone). N=15 glomeruli from 3 rats (5 glomeruli from each rat) in each group.