Table 2. Endothelial Cell Density Examined by Contact Specular Microscopy Before and After the Administrations of Ripasudil in Instilled Eye.
N/A = not able to be calculated or unreliable data, SD = standard deviation. Values are the number of corneal endothelial cells (/mm2).
| Subject | Day 0 | Day 7 | Follow-up | ||||
|---|---|---|---|---|---|---|---|
| Pre a | 1.5 hrs. | 6 hrs. | 0 hr b | 1.5 hrs. | 6 hrs. | ||
| 1 | 3175 | 3135 | 3155 | 3390 | 3378 | 3378 | 3300 |
| 2 | 2646 | N/A | 2688 | 2604 | N/A | 2611 | 2545 |
| 3 | 3125 | 3115 | 3226 | 3215 | 3145 | 3165 | 3145 |
| 4 | 2283 | 2247 | 2353 | 2525 | 2506 | 2564 | 2421 |
| 5 | 2755 | N/A | 2725 | 2849 | N/A | 2933 | 2833 |
| 6 | 3058 | N/A | 2941 | 2967 | N/A | 2994 | 3096 |
| Mean | 2840.3 | - | 2848.0 | 2925.0 | - | 2940.8 | 2890.0 |
| SD | 345.3 | - | 326.0 | 337.9 | - | 314.7 | 351.5 |
a Before the administration of ripasudil.
b Before the final administrations of ripasudil (Twelve hours after administration).