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. 2015 Sep 14;10(9):e0137696. doi: 10.1371/journal.pone.0137696

Fig 2. 3’-UTRs become divergent across evolution while conserving regulatory motifs.

Fig 2

A) Representation of the lengths of divergent species 3’-UTR Jak2 lengths. There is a significant degree of variation across evolution, however as seen in panel B regions of these UTRs have been conserved. B) This alignment was generated from RPTS, it utilizes the multiple sequence comparison by log-expectation (Clustal-Ω) alignment method to determine regions of highest conservation in Jak2 [16–18]. Purines and Pyrmidines are differentiated by pink and blue, respectively. C) Our training GEO set GSE40466 yielded a consensus nucleic acid sequence specific to binding hnRNP E1, in addition to determining a consensus sequence, the output includes the identity of genes that contain this motif. When the consensus sequence was analyzed by BLASTn, 92.7% of the genes predicted by BLAST analysis were also predicted by RPTS.